With flood waters advancing on central Bangkok, Australians are being urged not to travel to the Thai capital.
Thousands of Bangkok residents flocked to bus, rail and air terminals to make their exodus, while heavy traffic snaked out of the sprawling Thai capital.
Water was seeping into central areas of the city of 12 million people, entering the grounds of the Grand Palace after the main Chao Phraya river overflowed at high tide, but most of downtown Bangkok was still dry.
A huge run-off from the north equivalent to almost half a million Olympic swimming pools is expected to reach the capital at the same time as seasonal high tides this weekend, testing the city's flood defences.
Australia's Department of Foreign Affairs says Bangkok's Suvarnabhumi International Airport is operating normally at present, but the old airport in the city's north, Don Muang, has been closed.
Many residents hunkered down in their homes, surrounded by sandbags or in some cases hastily erected concrete block walls, after the government ordered a five-day holiday for 21 provinces including Bangkok from Thursday.
"It's a crisis, because if we try to resist this massive amount of floodwater, a force of nature, we won't win," said teary-eyed prime minister Yingluck Shinawatra, facing a major test of her two-month-old leadership.
"But if we allow it to flow freely, then people in many areas are prepared."
Crowds of people abandoned their homes and headed to areas away from the path of the water, especially to the beach resorts of Hua Hin, Phuket and Pattaya.
"All of these destinations are packed with Thais who have moved from Bangkok," said Tourism Authority of Thailand deputy chief Sansern Ngaorungsi.
He said domestic flights from Suvarnabhumi airport were also "very, very packed".
"I saw on the news that the water is getting closer. Maybe it's not going to come but I don't want to take a chance," 72-year-old Canadian Claude Kerrignan said as he waited to board a bus to Pattaya.
"Many people in my building have left already. Around where I live they have sandbags four feet high, but if what they say is true, it's going to be higher than that."
Supplies running low
Government offices, schools and some businesses were shut across Bangkok, where supermarkets have been running low on - and sometimes rationing - essential items such as bottled water and eggs as residents stock up.
"For a lot of people right now access to drinking water is one of the concerns," said Jerry Velasquez, regional coordinator for the International Strategy for Disaster Reduction, a UN agency.
"Bangkok is still in the early phase. This is a once in a 100 years flood. This is intense."
Much of the country has already been ravaged by the three-month flood crisis caused by unusually heavy monsoon rains, which has left more than 370 people dead and millions of homes and livelihoods damaged.
Ms Yingluck admitted the situation in the capital was critical, with the government preparing extra shelters for Bangkok evacuees, who already exceed 7,500.
Tens of thouands of troops have joined the flood relief efforts.
The crisis is taking its toll on the lucrative Thai tourism industry; as well as Australia, countries including Britain, Singapore, Canada and the Netherlands are advising against all but essential travel to Bangkok.
Thousands of inundated factories have also been shut down, putting more than half a million people temporarily out of work and disrupting global supply chains.